Transcriptomics

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NGLY1-deficient cerebral organiods display abnormal neuronal differentiation


ABSTRACT: We report using a single-cell transcriptomic study of cerebral organiods (COs) developed from WA09 hESCs with gene editing-induced NGLY1 mutations and from NGLY1-deficient patient's hiPSCs at 40 or 80 days of development. WA09 hESC-derived COs with and without mutant NGLY1 and patient's hiPSC-derived COs with and without the ectopic expression NGLY1 were analyzed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142143 | GEO | 2020/12/16

REPOSITORIES: GEO

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