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Hepatic transcriptome response to high dietary cholesterol intake in pig NAFLD model

ABSTRACT: The mechanisms by which cholesterol promotes NAFLD remain far less clear. Animal models are necessary to explore the pathogenesis and therapies of NAFLD. Several previous studies have shown that pig breeds can differ in their metabolic phenotype in response to high-energy diet. To investigate whether genetic background has profound effects on pig NAFLD phenotype and their metabolic response to dietary cholesterol intake, we performed RNA-Seq on liver tissues from two miniature pig breeds fed either standard or a high-fat and high-cholesterol diet for 6 months.

ORGANISM(S): Sus scrofa

PROVIDER: GSE142346 | GEO | 2022/12/15

REPOSITORIES: GEO

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Characterization of whole blood gene and while blood cell expression profiles of dietary-induced hyperlipidemia in miniature pigs

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Hepatic transcriptome response to high dietary cholesterol intake in pig NAFLD model

Project description:Hepatic transcriptome response to high dietary cholesterol intake in pig NAFLD model

| PRJNA596671 | ENA

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