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Bulk RNA-sequencing of microglia in 3XTg-AD mice treated with anti-Nk1.1 depleting antibodies or isotype control

ABSTRACT: The goal of this experiment is to determine the effects of NK cells on microglia inflammation in 3XTg-AD mice. We examined the transcriptomal changes of microglia in mice treated with anti-NK1.1 anitbodies and isotype controls by deep RNA-Seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE142875 | GEO | 2020/06/08

REPOSITORIES: GEO

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Single cell RNA-sequencing of microglia in 3XTg-AD mice treated with anti-Nk1.1 depleting antibodies or isotype control

Project description:This project aims to understand the effects of NK cell depletion in the single-cell gene expression of microglia in mice with Alzheimer's disease pathology. We used 10Xgenomics technique to examine the single-cell transcriptomes of microglia in mice treated with anti-NK1.1 depleting antibodies and isotype controls.

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Bulk RNA-sequencing of microglia in 3XTg-AD mice treated with anti-Nk1.1 depleting antibodies or isotype control

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Single cell RNA-sequencing of NK cells from control wildtype and 3XTg-AD mice

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Transcriptomes of Neural Stem and Progenitor Cells from the subgranular zone (SGZ) of Wild Type (NTG) and 3xTg-AD mice at juvenile age

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Senescent cell elimination modifies features of Alzheimer’s disease in 3xTg-AD mice

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2022-02-01 | GSE190607 | GEO

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