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Gene expression profiling of mouse CRTC1-MAML2-driven MEC-like tumors

ABSTRACT: We established a transgenic CRTC1-MAML2 fusion mouse model and crossed it with the MMTV-Cre transgenic mouse line to induce Cre expression and consequently the CRTC1-MAML2 fusion transgene expression in salivary glands. We observed that Cre-induced CRTC1-MAML2 transgene expression caused the formation of salivary gland tumors resembling the histological features of human MEC. Here we performed genome-wide gene expression profiling analysis to characterize the transcriptomic feature of these murine CRTC1-MAML2-driven MEC-like tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE143264 | GEO | 2024/05/10

REPOSITORIES: GEO

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