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BCL9/STAT3 Regulation of Transcriptional Enhancer Networks Promote DCIS Progression

ABSTRACT: There is limited research on which specific Wnt targets are regulated by B-Cell Lymphoma-9 (BCL9) and whether BCL9 regulates other signaling pathways to drive cancer malignancy. Here, using ChIP-Exo we have demonstrated that BCL9 in a protein complex with STAT3 drives DCIS invasive progression by regulation of enhancers and enhancer associated target genes involved in cellular growth, invasion and migration.

ORGANISM(S): Homo sapiens

PROVIDER: GSE143313 | GEO | 2020/01/09

REPOSITORIES: GEO

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BCL9/STAT3 Regulation of Transcriptional Enhancer Networks Promote DCIS Progression

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