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Spermidine synthase regulates extracellular vesicle secretion in castration resistant prostate cancer.

ABSTRACT: Extracellular vesciles (EVs) have an important role in the tumor progression. However, the precise regulatrory mechanisms of EV secretion has not been clarified yet. We performed quantitive high-throughput screening to eluciade the key miRNAs for EV biogenesis in castration resistant prostate cancer (CRPC) using 22RV1 cells, and miR-1908 was selected as the miRNA regulating EV biogenesis in CRPC. To identify the genes that could be targeted by miR-1908, we performed mRNA micorarray analysis in 22RV1 after transfected of miR-1908 mimic or control miRNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE143350 | GEO | 2020/06/21

REPOSITORIES: GEO

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