Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity [ChIP-seq]

ABSTRACT: In this project, we studied how the nucleosome binding protein HMGN1 affects myeloid differentiation and hematopoietic and leukemia stem cell activity.

ORGANISM(S): Mus musculus

PROVIDER: GSE143682 | GEO | 2020/02/05

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity [ATAC-seq]

Project description:In this project, we studied how the nucleosome binding protein HMGN1 affects myeloid differentiation and hematopoietic and leukemia stem cell activity.

2020-02-05 | GSE143840 | GEO

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity [RNA-seq]

Project description:In this project, we studied how the nucleosome binding protein HMGN1 affects myeloid differentiation and hematopoietic and leukemia stem cell activity

2020-02-05 | GSE142473 | GEO

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

Project description:Chromatin organization is a highly orchestrated process that influences gene expression, in part by modulating access of regulatory factors to DNA and nucleosomes. We found that the chromatin accessibility regulator HMGN1, a target of recurrent DNA copy gains in leukemia, controls myeloid differentiation. HMGN1 amplification was associated with increased accessibility, expression, and histone H3K27 acetylation of loci important for hematopoietic stem cell (HSC) function and AML, such as HoxA cluster genes. In vivo, HMGN1 overexpression was linked to decreased quiescence and increased HSC activity in bone marrow transplantation. HMGN1 overexpression also cooperated with the AML-ETO9a fusion oncoprotein to impair myeloid differentiation and enhance leukemia stem cell (LSC) activity. Inhibition of histone acetyltransferases CBP/p300 relieved the HMGN1-associated differentiation block. These data nominate factors that modulate chromatin accessibility as regulators of HSCs and LSCs and suggest that targeting HMGN1 or its downstream effects on histone acetylation could be therapeutically active in AML.

2020-02-25 | PXD017054 | Pride

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity.

Project description:Chromatin organization is a highly orchestrated process that influences gene expression, in part by modulating access of regulatory factors to DNA and nucleosomes. Here, we report that the chromatin accessibility regulator HMGN1, a target of recurrent DNA copy gains in leukemia, controls myeloid differentiation. HMGN1 amplification is associated with increased accessibility, expression, and histone H3K27 acetylation of loci important for hematopoietic stem cells (HSCs) and leukemia, such as HoxA cluster genes. In vivo, HMGN1 overexpression is linked to decreased quiescence and increased HSC activity in bone marrow transplantation. HMGN1 overexpression also cooperates with the AML-ETO9a fusion oncoprotein to impair myeloid differentiation and enhance leukemia stem cell (LSC) activity. Inhibition of histone acetyltransferases CBP/p300 relieves the HMGN1-associated differentiation block. These data nominate factors that modulate chromatin accessibility as regulators of HSCs and LSCs, and suggest that targeting HMGN1 or its downstream effects on histone acetylation could be therapeutically active in AML.

| S-EPMC7076002 | biostudies-literature

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

Project description:Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

| PRJNA601226 | ENA

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity [RNA-seq]

Project description:Chromatin accessibility promotes hematopoietic and leukemia stem cell activity [RNA-seq]

| PRJNA597107 | ENA

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity [ATAC-seq]

Project description:Chromatin accessibility promotes hematopoietic and leukemia stem cell activity [ATAC-seq]

| PRJNA601825 | ENA

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity [ChIP-seq]

Project description:Chromatin accessibility promotes hematopoietic and leukemia stem cell activity [ChIP-seq]

| PRJNA601228 | ENA

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-02-04 | GSE143683 | GEO

CD38 enzymatic activity promotes hematopoietic stem cell dormancy

Project description:CD38 enzymatic activity promotes hematopoietic stem cell dormancy

| PRJNA807170 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data