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Gene expression profiles in BMDM cells of Trex1-KO and wild-type mice after treatment of STING antagonists

ABSTRACT: Mounting evidence demonstrates that cGAS-STING signaling is the major pathway in sensing cytosolic DNAs. However, aberrant accumulation of self DNA molecules in Trex1 (a 3'-to-5' DNA exonuclease) deficient cells usually causes over-activation of cGAS-STING signaling, which is associated with the pathology of several autoimmune diseases. Here, we investigated gene expression changes in BMDM cells of Trex1 knockout mice after manipulating cGAS-STING signaling activity via treatment of two STING antagonists (SN-011 and H151) .

ORGANISM(S): Mus musculus

PROVIDER: GSE143830 | GEO | 2021/05/26

REPOSITORIES: GEO

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