Genomics

Dataset Information

0

Androgen Receptor splice variant V7 (AR-V7) mediates AR signalling in castration resistant prostate cancer (CRPC) [ChIP-exo]


ABSTRACT: CRPC remains AR dependent. There are multiple mechanisms for reactivation of AR including expression of constitutively active AR splices variant AR-V7 (AR3). Earlier studies suggest that though the variants regulate many of the same genes as AR, they also have unique targets. Another argument is that the variant is a “weak” AR. We have used an LNCaP cell line that expresses AR-V7 in response to doxycycline to compare DNA interactions of the two isoforms and to identify differential regulation of target genes. ChIP-exo method was used to map AR and AR-V7 interaction with DNA in LNCaP engineered cell line (LNCaP AR-V7) at single base resolution.

ORGANISM(S): Homo sapiens

PROVIDER: GSE143906 | GEO | 2021/07/07

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-01-21 | GSE143905 | GEO
2021-12-31 | GSE184676 | GEO
2018-08-16 | GSE104572 | GEO
2024-06-05 | GSE221141 | GEO
2024-06-05 | GSE221140 | GEO
2024-06-05 | GSE221137 | GEO
2020-11-02 | GSE122922 | GEO
2018-10-19 | GSE118435 | GEO
| PRJNA602078 | ENA
2015-02-10 | E-GEOD-65738 | biostudies-arrayexpress