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Transcriptomic analysis of airway macrophages from preschool wheeze

ABSTRACT: Preschool wheeze is an early life bronchoconstriction disorder with an increased risk of progression to chilhood asthma. Preschool wheeze is typically triggered by respiratory infection, but airway inflammatory phenotypes, including the phenotype of airway macrophages (AMs), in preschool wheeze is not fully understood. In this study, AMs were sorted from preschool wheeze patients and non-wheezing paediatric controls under clinical investigation for chronic cough and gene expression assessed by Illumina mRNA sequencing (110 base pair, paired end reads). A number of differentially expressed genes were observed in AMs from preschool wheeze compared to those from controls, including genes encoding pro-inflammatory chemokines and genes associated with a more immature and inflammatory AM phenotype. These findings suggest that AMs contribute to an altered airway immune landscape in preschool wheeze.

ORGANISM(S): Homo sapiens

PROVIDER: GSE144033 | GEO | 2021/05/12

REPOSITORIES: GEO

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Impaired interferon response in plasmacytoid dendritic cells from children with persistent wheeze

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