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Transcriptional regulation of cell division and cytokinin response in Arabidopsis shoot apical meristem

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE144049 | GEO | 2021/03/26

REPOSITORIES: GEO

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Transcriptional regulation of cell division and cytokinin response in Arabidopsis shoot apical meristem [ChIP-seq]

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Transcriptional regulation of cell division and cytokinin response in Arabidopsis shoot apical meristem [RNA-seq]

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Transcriptional regulation of cell division and cytokinin response in Arabidopsis shoot apical meristem

Project description:Transcriptional regulation of cell division and cytokinin response in Arabidopsis shoot apical meristem

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Analysis of cell division patterns in the Arabidopsis shoot apical meristem.

Project description:The stereotypic pattern of cell shapes in the Arabidopsis shoot apical meristem (SAM) suggests that strict rules govern the placement of new walls during cell division. When a cell in the SAM divides, a new wall is built that connects existing walls and divides the cytoplasm of the daughter cells. Because features that are determined by the placement of new walls such as cell size, shape, and number of neighbors are highly regular, rules must exist for maintaining such order. Here we present a quantitative model of these rules that incorporates different observed features of cell division. Each feature is incorporated into a "potential function" that contributes a single term to a total analog of potential energy. New cell walls are predicted to occur at locations where the potential function is minimized. Quantitative terms that represent the well-known historical rules of plant cell division, such as those given by Hofmeister, Errera, and Sachs are developed and evaluated against observed cell divisions in the epidermal layer (L1) of Arabidopsis thaliana SAM. The method is general enough to allow additional terms for nongeometric properties such as internal concentration gradients and mechanical tensile forces.

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Transcriptional regulation of cell division and cytokinin response in Arabidopsis shoot apical meristem [ChIP-seq]

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Project description:Transcriptional regulation of cell division and cytokinin response in Arabidopsis shoot apical meristem [RNA-seq]

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Topological properties accurately predict cell division events and organization of shoot apical meristem in Arabidopsis thaliana.

Project description:Cell division and the resulting changes to the cell organization affect the shape and functionality of all tissues. Thus, understanding the determinants of the tissue-wide changes imposed by cell division is a key question in developmental biology. Here, we use a network representation of live cell imaging data from shoot apical meristems (SAMs) in Arabidopsis thaliana to predict cell division events and their consequences at the tissue level. We show that a support vector machine classifier based on the SAM network properties is predictive of cell division events, with test accuracy of 76%, which matches that based on cell size alone. Furthermore, we demonstrate that the combination of topological and biological properties, including cell size, perimeter, distance and shared cell wall between cells, can further boost the prediction accuracy of resulting changes in topology triggered by cell division. Using our classifiers, we demonstrate the importance of microtubule-mediated cell-to-cell growth coordination in influencing tissue-level topology. Together, the results from our network-based analysis demonstrate a feedback mechanism between tissue topology and cell division in A. thaliana SAMs.

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