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Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells

ABSTRACT: We report the effects of acute M2-like macrophage enrichment in a mouse closed head injury model of diffuse traumatic brain injury. Enrichment is achieved by engineering mesenchymal stromal cells with synthetic interleukin-4 (IL-4) mRNA to transiently express IL-4. Through a transcriptomic analysis of treated brain tissue, we begin to understand the effects of acute IL-4 and M2-like macrophage enrichment.

ORGANISM(S): Mus musculus

PROVIDER: GSE144193 | GEO | 2020/01/25

REPOSITORIES: GEO

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Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells

Project description:Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells

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