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Roles of Mafb and c-Maf in MGE-derived pallial interneuron development and maturation

ABSTRACT: We utilized single-cell RNA-sequencing to identify candidate genetic targets of Mafb and c-Maf in the MGE-lineage using Nkx2.1-Cre generated neonatal wildtype (WT) and conditional Mafb/c-Maf double deletion mutant (cDKO) animals. We identified genes that likely contribute to Maf cDKO's phenotypes, which include preferential parvalbumin interneuron loss, overproduction of hippocampal interneurons and neurite outgrowth defects.

ORGANISM(S): Mus musculus

PROVIDER: GSE144222 | GEO | 2020/06/04

REPOSITORIES: GEO

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Roles of Mafb and c-Maf in MGE-derived pallial interneuron development and maturation

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