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Change in expression of genes after retinoic acid treatment of stellate cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE14427 | GEO | 2011/12/30

SECONDARY ACCESSION(S): PRJNA111753

REPOSITORIES: GEO

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Change in expression of genes after retinoic acid treatment of stellate cells

Project description:This SuperSeries is composed of the following subset Series: GSE14425: Change in expression of genes after retinoic acid treatment of stellate cells: Dose response GSE14426: Change in expression of genes after retinoic acid treatment of stellate cells: Time Course Refer to individual Series

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Project description:We evaluated the change in expression of genes after treatment of stellate cells with retinoic acid to understand how the stellate cells can de-differentiate and effect their physiological behaviour in pathological conditions. We then tested the changes in the gene expression in 2D and 3D culture conditions for pancreatic stellate cells and in a pancreatic cancer model. Keywords: gene expression change, dose response, matrix conditions We treated a pancreatic stellate cell line on plastic or Matrigel with 1 or 10 micromolar dose of all-trans retinoic acid (ATRA). RNA was extracted and hybridized on Illumina Human microarrays. We looked for target genes regulated by ATRA and evaluated for dose repsonse and change due to background culture conditions.

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Change in expression of genes after retinoic acid treatment of stellate cells: time course

2011-12-30 | GSE14426 | GEO

Change in expression of genes after retinoic acid treatment of stellate cells: dose response

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Change in expression of genes after retinoic acid treatment of stellate cells: dose response

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Project description:We evaluated the change in expression of genes after treatment of stellate cells with retinoic acid to understand how the stellate cells can de-differentiate and effect their physiological behaviour in pathological conditions. We then tested the changes in the gene expression in 2D and 3D culture conditions for pancreatic stellate cells and in a pancreatic cancer model. Keywords: gene expression change, time course We treated a pancreatic stellate cell line on plastic with 1 micromolar all-trans retinoic acid (ATRA) for timepoints of 30 mins, 4 hours, 12 hours, 24 hours and 168 hours. RNA was extracted and hybridized on Illumina Human microarrays. We looked for target genes regulated by ATRA and evaluated for time course change.

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