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HIF-1a tunes T follicular helper cell differentiation during acute viral infection

ABSTRACT: T follicular helper (Tfh) cells provide signals to initiate and maintain the germinal center (GC) reaction and are crucial for the generation of robust antibody responses. We found that hypoxia inducible factor-1 (HIF-1a) is an inhiibitor of Tfh generation in a mouse model of acute viral infection, and that HIF-1a mediates its effects by suppressing mTORC1 activity.

ORGANISM(S): Mus musculus

PROVIDER: GSE144467 | GEO | 2021/12/10

REPOSITORIES: GEO

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HIF-1a tunes T follicular helper cell differentiation during acute viral infection

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