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Gene expression profiles of spontaneous metastasis in a K-ras/p53 mutant mouse model

ABSTRACT: The biologic basis for NSCLC metastasis is not well understood. Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified 2,209 genes that were differentially expressed in distant metastases relative to matched lung tumors. Mining of publicly available data bases revealed this expression signature in a subset of NSCLC patients who had a poorer prognosis than those without the signature.

ORGANISM(S): Mus musculus

PROVIDER: GSE14449 | GEO | 2009/04/15

SECONDARY ACCESSION(S): PRJNA114501

REPOSITORIES: GEO

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