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Effect of lutein on worms lacking complex I subunit nuo-5 (ortholog of human NDUFS1)

ABSTRACT: To gain insight into the pathways accounting for the deleterious effects associated with severe mitochondrial dysfunction, we compared the transcriptomic profile in control L3 larvae with that of strong (arrested) nuo-5 RNAi. We also found that the natural compound lutein was able to rescue some of the defective phenotypes we characterized in nuo-5-depleted animals therefore we compared also the transcriptomic profile of stage-matched (L3) cohorts of C. elegans upon strong nuo-5 RNAi, treated and untreated with lutein, with that of animals fed empty vector control.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE144574 | GEO | 2020/01/31

REPOSITORIES: GEO

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