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JUN induction in osteoprogenitors

ABSTRACT: Different osteoprogenitors (SSC, BCSP, Thy+) were sorted after 2 days of JUN induction, followed by RNA extraction and microarray analysis

ORGANISM(S): Mus musculus

PROVIDER: GSE144829 | GEO | 2020/02/07

REPOSITORIES: GEO

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JUN induction in osteoprogenitors

Project description:JUN induction in osteoprogenitors

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c-Jun protein expression in vivo induces systemic fibrosis in mice

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Transcriptome analysis of JUN overexpressed or JUN inactivated fibroblasts

Project description:To examine the effects of phosphorylated JUN-mediated enhancers activation on gene expression, we conducted RNA-seq analysis in JUN wildtype (WT) or JUN inactive mutant (JUN AA) overexpressed MRC5 cells. The expression levels of genes associated with JUN-activated enhancers are significantly upregulated in JUN WT cells rather than in JUN AA cells. To quantify the effects of JUN inactivation on gene expression, we also performed RNA-seq analysis in JNKi-treated induced CAFs (iCAFs). We observed that JNKi significantly reduced expression levels of JUN-activated enhancers-associated genes.

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Genome wide chromatin accessibilty changes associated with JUN expression in human normal and IPF lung fiborblasts

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Genome wide chromatin accessibilty changes associated with JUN and SHH expression in human SSCL patients

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