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HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE144863 | GEO | 2020/11/01

REPOSITORIES: GEO

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HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells.

Project description:The heterochromatin protein 1 (HP1) family members are canonical effectors and propagators of gene repression mediated by histone H3 lysine 9 (H3K9) methylation. HP1γ exhibits an increased interaction with active transcription elongation-associated factors in embryonic stem cells (ESCs) compared to somatic cells. However, whether this association has a functional consequence remains elusive. Here we find that genic HP1γ colocalizes and enhances enrichment of transcription elongation-associated H3K36me3 rather than H3K9me3. Unexpectedly, sustained H3K36me3 deposition is dependent on HP1γ. HP1γ-deleted ESCs display reduced H3K36me3 enrichment, concomitant with decreased expression at shared genes which function to maintain cellular homeostasis. Both the H3K9me3-binding chromodomain and histone binding ability of HP1γ are dispensable for maintaining H3K36me3 levels. Instead, the chromoshadow together with the hinge domain of HP1γ that confer protein and nucleic acid-binding ability are sufficient because they retain the ability to interact with NSD1, an H3K36 methyltransferase. HP1γ-deleted ESCs have a slower self-renewal rate and an impaired ability to differentiate towards cardiac mesoderm. Our findings reveal a requirement for HP1γ in faithful establishment of transcription elongation in ESCs, which regulates pluripotency.

| S-EPMC7736818 | biostudies-literature

HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells (RNA-seq)

2020-11-01 | GSE144862 | GEO

HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells (ChIP-Seq)

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HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells

Project description:HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells

| PRJNA605165 | ENA

HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells (ChIP-Seq)

Project description:HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells (ChIP-Seq)

| PRJNA605172 | ENA

HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells (RNA-seq)

Project description:HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells (RNA-seq)

| PRJNA605171 | ENA

H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-05-13 | E-GEOD-69291 | biostudies-arrayexpress

The THO complex regulates pluripotency gene mRNA export to control embryonic stem cell self-renewal and somatic cell reprogramming

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-11-30 | E-GEOD-51534 | biostudies-arrayexpress

An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming

Project description:This SuperSeries is composed of the SubSeries listed below.

2011-09-15 | GSE30992 | GEO

H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium

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