Transcriptomics

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Gene profiling of Müller glia during early stages of zebrafish photoreceptor regeneration


ABSTRACT: Photoreceptor damage in adult mammals results in permanent cell loss and glial scarring in the retina. In contrast, adult zebrafish can regenerate photoreceptors following injury. By using a stable transgenic line in which GFP is driven by the cis-regulatory sequences of a glial specific marker gfap, Tg(gfap:GFP)mi2002, previous studies showed that Müller glia, the radial glial cells in the retina, proliferate after photoreceptor loss and give rise to neuronal progenitors that eventually differentiate into regenerated photoreceptors. To identify the molecular mechanisms that initiate this regenerative response, Müller glia were isolated from Tg(gfap:GFP)mi2002 fish during the early stages of regeneration after light lesion and gene expression profiles were generated by microarray analyses. Keywords: time course

ORGANISM(S): Danio rerio

PROVIDER: GSE14495 | GEO | 2009/02/04

SECONDARY ACCESSION(S): PRJNA111551

REPOSITORIES: GEO

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