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Analysis of apoptosis- and TGFB1-associated transcriptome changes in peripheral blood leukocytes during anti-EBV therapy

ABSTRACT: Refer to the SuperSeries

ORGANISM(S): Homo sapiens

PROVIDER: GSE145027 | GEO | 2020/02/11

REPOSITORIES: GEO

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Apoptosis-associated transcriptome changes in peripheral blood leukocytes during EBV antiviral therapy

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Analysis of apoptosis- and TGFB1-associated transcriptome changes in peripheral blood leukocytes during anti-EBV therapy

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Project description:Despite evidence linking obesity to impaired immune function, little is known about the specific mechanisms. Because of emerging evidence that immune responses are epigenetically regulated, we hypothesized that DNA methylation changes are involved in obesity induced immune dysfunction and aimed to identify these changes.We conducted a genome wide methylation analysis on seven obese cases and seven lean controls aged 14 to 18 years from extreme ends of the obesity distribution and performed further validation of six CpG sites from six genes in 46 obese cases and 46 lean controls aged 14 to 30 years.In comparison with the lean controls, we observed one CpG site in the UBASH3A gene showing higher methylation levels and one CpG site in the TRIM3 gene showing lower methylation levels in the obese cases in both the genome wide step (P = 5 × 10(-6) and P = 2 × 10(-5) for the UBASH3A and the TRIM3 gene respectively) and the validation step (P = 0.008 and P = 0.001 for the UBASH3A and the TRIM3 gene respectively).Our results provide evidence that obesity is associated with methylation changes in blood leukocyte DNA. Further studies are warranted to determine the causal direction of this relationship as well as whether such methylation changes can lead to immune dysfunction.

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Search for apoptosis-related transcriptome markers associated with herpesvirus infections in peripheral blood leukocytes

Project description:Proteins encoded by the herpesviridae family members interfere with apoptotic pathways helping the viruses to evade immune surveillance. The aim of the study is to reveal mRNA markers which could be clinically relevant for monitoring of the herpesvirus infections. Majority of the genes being investigated fall within the following categories - death receptors, adaptors, caspases, mitochondrial proteins associated with apoptosis, kinanses involved in apoptosis regulation and execution, splicing factors, transcription factors.

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Shorter telomere length in peripheral blood leukocytes is associated with childhood autism.

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