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Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

ABSTRACT: We report reproductive tract extracellular vesicles (EVs) transmit information regarding stress in the paternal environment to sperm, ultimately altering fetal development. Using intracytoplasmic sperm injection, we found that sperm incubated with EVs collected from stress-treated epididymal epithelial cells produced offspring with altered neurodevelopment and adult stress reactivity. Proteomic and transcriptomic assessment of these EVs showed dramatic changes in protein and miRNA content long after stress treatment had ended.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE145051 | GEO | 2020/02/11

REPOSITORIES: GEO

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Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

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