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Pooled CRISPR screens in human intestinal organoids [CUT&RUN]

ABSTRACT: We performed CRISPR screens on both a sub-library and a genome-wide scale in human intestinal organoids to discover cancer driver genes. We investigated the Wnt and the TGFB pathway and used both WT, APC-mutant and APC-TP53-mutant organoids.

ORGANISM(S): Homo sapiens

PROVIDER: GSE145183 | GEO | 2020/02/26

REPOSITORIES: GEO

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