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ChIP-seq of cholangiocytes treated with TGFbeta

ABSTRACT: TGF beta has profound effects on global gene expression changes. To understand the epigenetic mechanisms associated with TGF beta stimulation, we performed ChIP-seq of cholangiocytes to understand the changes in histone modifications associated with TGF beta. We choose H3K27ac and H3K9ac, histone modification associated with gene expression. These histone modifications were correlated with SMAD3 occupancy, which is a canonical downstream mediator of TGF beta signaling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE145250 | GEO | 2020/02/20

REPOSITORIES: GEO

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