Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression data from epididymal fat of systemic Iah1-knockout in A/J-12SM mouse

ABSTRACT: The QTL for fatty liver was mapped on mouse chromosome 12, designated as Fl1sa. Iah1 gene is a candidate gene for Fl1sa . In mammal, Iah1 function has been largely unknown. We constructed Iah1-knockout mouse in A/J-12SM background. Iah1 gene is abundantly expressed in epididymal fat of mouse. We compared the epididymal fat's gene expressions between Iah1-WT mouse and Iah1-KO mouse.

ORGANISM(S): Mus musculus

PROVIDER: GSE145750 | GEO | 2020/03/19

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression data from epididymal fat of A/J mouse and A/J-12SM consomic mouse

Project description:SMXA-5 mouse shows a high-fat induced fatty liver. The QTL for fatty liver was mapped on mouse chromosome 12, designated as Fl1sa. The liver weight and liver triglyceride content of A/J-12SM consomic mouse was lower than that of A/J mouse. In contrast, the epididymal fat weight tended to be higher in A/J-12SM consomic mouse than that in A/J. We compared the epididymal fat's gene expressions between A/J mouse and A/J-12SM consomic mouse.

2016-04-30 | GSE79281 | GEO

Gene expression data from liver of systemic Iah1-knockout mouse

Project description:SMXA-5 mouse shows a high-fat induced fatty liver. The QTL for fatty liver was mapped on mouse chromosome 12, designated as Fl1sa. Iah1 gene is a candidate gene for Fl1sa. We compared the liver's gene expressions between Iah1-WT mouse and Iah1-KO mouse.

2018-05-01 | GSE93688 | GEO

Gene expression data from kidney of systemic Iah1-knockout mouse

Project description:SMXA-5 mouse shows a high-fat induced fatty liver. The QTL for fatty liver was mapped on mouse chromosome 12, designated as Fl1sa. Iah1 gene is a candidate gene for Fl1sa. Kidney is the highest tissue of Iah1 gene expression in mouse. We compared the kidney's gene expressions between Iah1-WT mouse and Iah1-KO mouse.

2018-05-01 | GSE93687 | GEO

Hepatic gene expression data from A/J mouse and A/J-12SM consomic mouse

2016-02-29 | GSE67340 | GEO

Hepatic gene expression data from A/J mouse and A/J-12SM consomic mouse

Project description:SMXA-5 mouse shows a high-fat induced fatty liver. The QTL for fatty liver was mapped on mouse chromosome 12, designated as Fl1sa. The liver triglycerides content of A/J-12SM consomic mouse, a chromosome substitution strain, was suppressed compared to that of A/J mouse. We compared the hepatic gene expressions between A/J mouse and A/J-12SM consomic mouse. Total RNA of male A/J mice and A/J-12SM consomic mice fed a high-fat diet for 7weeks were extracted individually from liver of nine mice. The RNAs from three mice were pooled and hybridized on one Affimetrix microarray. Sample were analyzed in triplicate set of array (three biological replicates).

2016-02-29 | E-GEOD-67340 | biostudies-arrayexpress

Epididymal Adipose Tissue Profiling In HMDP

Project description:Identify genes in the epididymal adipose tissue whose expression is under genetic regulation in the hybrid mouse diversity panel. The hybrid mouse diversity panel is comprised of classical inbred and recombinant inbred wild type mice. The RMA values of genes were used for genome wide association as described in Bennett et al Genome Research 2010. These data are used to identify candidate genes at loci associated with obesity and dietary responsiveness. GWAS for expression of epididymal adipose tissue in inbred strains

2013-01-09 | E-GEOD-42890 | biostudies-arrayexpress

Critical Role of Runx Transcription Factors in Maintaining Epididymal Epithelial Differentiation [RNA-seq II]

Project description:To study the role of RUNX transcription factors in the epididymal epithelial cells we deleted Runt domains of Runx1 and Runx2 from mouse epididymal cell line mE-Cap18 using CRISPR-Cas9 technique.

2024-05-02 | GSE236104 | GEO

Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging

Project description:Introduction: Morphological and functional alternations of the aging reproductive organs result in decreased male fertility. We previously reported that the epididymal initial segment underwent remarkable histological changes and chronic immune-activation in mouse during aging. However, the local cell landscape in the aged epididymal initial segment are poorly understood. Objectives: We aimed to characterize the aging-associated cellular and molecular features of mouse epididymal initial segment.

2023-04-23 | GSE226310 | GEO

Gene expression data from epididymal fat of systemic Iah1-knockout in A/J-12SM mouse

Project description:Gene expression data from epididymal fat of systemic Iah1-knockout in A/J-12SM mouse

| PRJNA608127 | ENA

Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression

Project description:Sperm small RNAs have emerged as important non-genetic contributors to embryogenesis and offspring health. A subset of sperm small RNAs are thought to be acquired during epididymal transit. However, the transfer of RNAs from the somatic epididymis to the sperm has been questioned, and the identity of the specific small RNAs transferred remains unclear. Here, we employ Cre/Lox genetics to generate germline- and epididymal-specific Dgcr8 conditional knockout mice to investigate the dynamics of sperm microRNAs and their function in the early embryo. Interestingly, sperm from germline specific Dgcr8 knockout males restored the levels of 58 of the 98 (59%) miRNAs that were lost in testicular sperm during epididymal transit. Conversely, sperm from epididymal Dgcr8 knockouts displayed a 5-fold reduction in 25 miRNAs. This substantial loss of epididymal miRNAs in sperm was accompanied by transcriptomic changes in the embryo which was rescued by microinjection of epididymal miRNAs. These findings ultimately demonstrate the acquisition of miRNAs by sperm during epididymal transit and their regulation of post-fertilization embryonic gene expression.

2024-08-31 | GSE244885 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data