Hepatic transcriptome of eIF4EBP3 deficient mouse
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ABSTRACT: Previously we observed that when constantly reducing protein synthesis using the whole-body eIF2α haploinsufficient mouse model, the hepatic lipogenesis process would gear down. To figure out whether translation can regulate lipogenesis in a cell-autonomous way, we created the liver-specific eIF4EBP3 deficient mouse by adenovirus-mediated shRNA targeting Eif4ebp3. eIF4EBP3 suppresses translation initiation by sequestering eIF4E. Therefore, by knocking down it, we established a translation hyperactive state in liver.
ORGANISM(S): Mus musculus
PROVIDER: GSE146153 | GEO | 2022/03/01
REPOSITORIES: GEO
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