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Discovery of new imprinted genes by genome-wide DNA methylation comparison between human androgenetic and parthenogenetic induced pluripotent stem cells

ABSTRACT: Genomic imprinting is an epigenetic phenomenon in which the expression of a gene is determined in a parent-of-origin-dependent manner. Imprinted genes play an important role in the normal growth and development of mammals, and mutations at the imprinting sites result in gene dysfunction and many genetic disorders. To identify new human imprinted differentially methylated regions (DMRs), we compared the global levels of DNA methylation in androgenetic induced pluripotent stem cells and parthenogenetic induced pluripotent stem cells using DNA methyl-capture sequencing analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE146202 | GEO | 2021/02/22

REPOSITORIES: GEO

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