MiRNA expression profiling and identification of a miRNA regulator for axon guidance in the olfactory bulb of adult mice
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ABSTRACT: Using the highly sensitive miRNA array, we screened 40 microRNAs abundant in the olfactory bulb and we explored the functions of these miRNAs in the olfactory bulb by Gene Ontology and Kyoto Encyclopedia of Genes annotation. The enrichment results indicated that these miRNAs mainly participated in the axon guidance process. Furthermore, the quantitative real-time polymerase chain reaction, immunohistochemistry and dual luciferase reporter assay results showed that miR-30c is a specific regulator of semaphorin-3A, which will give new insights in disclosing the mechanism of functional maintenance and sexual-specific differentiation of the olfactory bulb.
ORGANISM(S): Mus musculus
PROVIDER: GSE146337 | GEO | 2020/09/18
REPOSITORIES: GEO
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