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RNA sequencing to identify UNC-49-regulated genes in C. elegans defense against pathogen infection

ABSTRACT: To gain molecular insights on how UNC-49 regulates C. elegans innate immunity, we used RNA sequencing to profile gene expression in unc-49(e407) animals relative to wild-type animals with or without P. aeruginosa(PA14) infection. We found that UNC-49 suppresses the expression of insulin pathway genes, and lack of UNC-49-mediated suppression in unc-49(e407) animals contributes to their improved survival against P. aeruginosa infection.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE146406 | GEO | 2023/10/23

REPOSITORIES: GEO

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