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Genetic dissection of a super enhancer controlling the Nppa-Nppb locus in the heart (CUT&RUN)

ABSTRACT: CUT&RUN H3K27ac PCM-1 sorted left ventricle of Nppa-Nppb double-knockout

ORGANISM(S): Mus musculus

PROVIDER: GSE146734 | GEO | 2020/11/25

REPOSITORIES: GEO

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Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress

Project description:The paralogous genes Nppa and Nppb are organized in an evolutionary conserved cluster and are a valuable model to study coregulation and regulatory landscape organization during heart development and disease. Here, we analyzed the chromatin conformation, epigenetic status and enhancer potential of sequences of the Nppa-Nppb cluster in vivo. Our data indicate that the regulatory landscape of the cluster is present within a 60 kbp domain centered around Nppb. Both promoters and several potential regulatory elements interact with each other in a similar manner in different tissues and developmental stages. The distribution of H3K27ac and the association of Pol2 across the locus changed during cardiac hypertrophy, revealing their potential involvement in stress-mediated gene regulation. In summary, the developmental regulation and stress-response of the Nppa-Nppb cluster involve the concerted action of multiple enhancers and epigenetic changes distributed across a structurally rigid regulatory domain. We have used 4C-seq on several viewpoints around the Nppa-Nppb gene cluster in the heart and liver samples to investigate the role of chromatin conformation on regulation of Nppa and Nppb expression during heart development and disease.

2016-07-02 | E-GEOD-81057 | biostudies-arrayexpress

Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress

2016-07-02 | GSE81057 | GEO

Genetic dissection of a super enhancer controlling the Nppa-Nppb locus in the heart (RNA-Seq)

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Genetic dissection of a super enhancer controlling the Nppa-Nppb locus in the heart (CUT&RUN)

Project description:Genetic dissection of a super enhancer controlling the Nppa-Nppb locus in the heart (CUT&RUN)

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Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart

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Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart after cardiac stress

Project description:High-resolution chromosome conformation capture-sequencing of wildtype mice left ventricle after cardiac stress (i.e. hypertrophy and myocardial infarction)

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Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart of RE3 mutants

Project description:Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart of RE3 mutants

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Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart after cardiac stress

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Genetic dissection of a super enhancer controlling the Nppa-Nppb locus in the heart (RNA-Seq)

Project description:Whole transcriptome expression analysis of RE1-deficient mice

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Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart

Project description:This SuperSeries is composed of the SubSeries listed below.