Transcriptomics

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Mast cells elicit protection against colorectal tumors by modulating the immune response during early tumorigenic steps


ABSTRACT: Mast cells (MC) alter the development of colorectal cancer (CRC), although their precise role remains poorly defined. Here we show that MC numbers vary in CRC patients, which directly impacts on lymphocytes population. Mouse-based mechanistic experiments reveal that an intricate MC-lymphocyte axis can either promote or inhibit the CRC development, as well as be pharmacologically explored. Therefore, MC activity can be modulated and inhibit the early steps of CRC development.

ORGANISM(S): Mus musculus

PROVIDER: GSE146786 | GEO | 2020/03/13

REPOSITORIES: GEO

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