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ChIP-seq BHT-101 cells and BHT-101 ASH1L KO cell lines

ABSTRACT: The goal of this study is to assess the role of ASH1 like histone lysine methyltransferase (ASH1L) in the biology of anaplastic thyroid cancer. CRISPR-Cas9 was used to create cell lines derived from BHT-101 anaplastic thyroid cancer cells with premature stop codons prior to the catalytic domain within both alleles of ASH1L. ChIP-seq for H3K36me2, the histone mark catalyzed by ASH1L, was performed on two KO cell lines, and compared to wild type BHT-101 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE147074 | GEO | 2020/05/09

REPOSITORIES: GEO

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