Candida albicans phagocytosed by macrophages: intact vs. ruptured phagosomes
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ABSTRACT: Transcriptional profiling of Candida albicans after 3 h phagocytosis by vehicle DMSO-treated macrophages (intact, expanding phagosomes) or calcium chelator BAPTA-AM-treated macrophages (inhibits lysosomal repair of expanding phagosomes, leading to phagosome rupture) to determine the effect of preventing phagosome expansion on C. albicans gene expression after phagocytosis by macrophages. Cultivation of Candida only for 3 h in DMEM-FBS cell culture medium or YPD complex medium as non-phagocytosis control conditions.
ORGANISM(S): Candida albicans
PROVIDER: GSE147207 | GEO | 2020/10/05
REPOSITORIES: GEO
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