Transcriptomics

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Single-cell ATAC-Sequencing of adipose Treg cells


ABSTRACT: Systematic characterizations of adipose Treg subsets and their in vivo roles remain uncommon. The goal of this study is to reveal the heterogeneity and chromatin landscape of adipose Treg cells. Using single-cell ATAC-seq to map adipose Treg cells, we identified different adipose subsets. Strikingly, our scATAC-seq analysis revealed a strong enrichment of key transcription factor motifs, which may play function in fate specification. By gain and loss of function studies, we further demonstrated adipose Treg subsets display disparate physiologic influences. Our findings have important implications for understanding phenotypic diversity of tissue Tregs in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE147768 | GEO | 2021/07/15

REPOSITORIES: GEO

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