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IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancer

ABSTRACT: We identified IGF2BP1 as a marker of the C5 molecular subtype of high-grade ovarian carcinoma (HG-SOC). IGF2BP1 promotes SRC activity and ERK2 expression enhancing the tolerance towards SRC- and MEK-directed inhibitors saracatinib and selumetib. Combination treatment overcomes IGF2BP1-promoted resistance.

ORGANISM(S): Homo sapiens

PROVIDER: GSE147980 | GEO | 2020/08/24

REPOSITORIES: GEO

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IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancer

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