Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptiomics profiling of brown adipose tissue of adipocyte-specific Beclin1 knockout mice

ABSTRACT: Adipose mRNA profiles of wildetype and Beclin1 knockout (tamoxifen-induced Adipoq-CreER/Beclin1(floxed/floxed)) mice were generated by deep sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE148275 | GEO | 2020/05/26

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptomics profiling of white adipose tissue of macrophage-specific Gja1 Knockout mice fed a normal chow diet (NCD) and high fat diet (HFD)

Project description:Adipose mRNA profiles of wild-type and Gja1 knockout (tamoxifen-induced Csf1r-CreER/ Gja1(floxed/floxed)) mice were generated by deep sequencing.

2022-06-01 | GSE204794 | GEO

Transcriptiomics profiling of brown adipose tissue of adipocyte-specific Beclin1 knockout mice

Project description:Transcriptiomics profiling of brown adipose tissue of adipocyte-specific Beclin1 knockout mice

| PRJNA623637 | ENA

RNA sequencing of inguinal white adipose tissue from seipin-deficient mice and appropriate controls

Project description:We generated Bscl2lox/lox mice X ERT2-Adipoq-CRE mice, allowing inducible seipin deletion in adipocytes upon tamoxifen addition (iATSKO). Indeed, a 5-day tamoxifen treatment led to a dramatic decrease in Bscl2 mRNA in the adipose tissue. To study the effects of seipin deficiency in vivo on adipose tissue homeostasis in an unbiased manner, we used 3’-signal recognition particle (SRP) RNA sequencing.

2022-01-11 | GSE188544 | GEO

The effect of adipose tissue-specific overexpression of adrenomedullin 2 on the regulation of adipocyte function

Project description:To investigate the effect of adipose tissue-specific overexpression of adrenomedullin 2 on the regulation of adipocyte function, the transgenic mouse line with adipocyte-specific overexpression of the ADM2 gene (aADM2-tg mice) was generated on a C57BL/6J background with the human ADM2 gene driven by the adiponectin (Adipoq) gene promoter (H11-Adipoq-hADM2-Wpre-PolyA mice, Strain NO. T059304). The mice were purchased from GemPharmatech (Nanjing, China). We then performed gene expression profiling analysis using data obtained from RNA-seg of visceral adipose tissue from aADM2-Tg and WT group.

2024-09-18 | GSE267858 | GEO

Inhibition of AXL Receptor Tyrosine Kinase Enhances Brown Adipose Tissue Functionality in mice [NovaSeq]

Project description:To identify transcriptomic differences in interscapular brown adipose tissue depots from HFD-challenged wild-type (Axl-floxed Cre-) vs. iFAXLKO (Axl-floxed Cre+) mice

2023-06-22 | GSE231470 | GEO

Prdm16 Knockout Brown Adipose Tissue

2014-04-09 | GSE55080 | GEO

Mouse retina from Msi1/Msi2 double knockout in photoreceptor cells

Project description:This quantitative protepomics study (TMT10 isobaric labeling) of the protein expression in the retina of Msi1/Msi2 double knockout mouse compared to floxed controls. The Msi1 and Msi2 genes were knocked out in photoreceptor cells using tamoxifen inducible Cre (Cre-ERT2) under the control of Pde6g promoter. Tamoxifen was administered by intrapertoneal injection for three consecutive day starting at postnatald day 30, and the retina was collected at postnatal day 51. Retinas from floxed animals lacking the Cre recombinase and treated with tamoxifen were used as controls. Five biological replicates for each knockout (three femailes, two males) and control (two femaes and three males) group were used.

2022-03-10 | PXD030748 | Pride

Ebf2 Knockout Brown Adipose Tissue

Project description:Ebf2 Knockout Brown Adipose Tissue

| PRJNA380740 | ENA

Prdm16 Knockout Brown Adipose Tissue

Project description:Gene expression profile from brown adipose tissues of Prdm16 knockout and wile type mice. Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and beige adipocytes. However, whether Prdm16 is required for the development or physiological function of brown adipose tissue (BAT) in vivo has been unclear. By analyzing mice that selectively lacked Prdm16 in the brown adipose lineage, we found that Prdm16 was dispensable for embryonic BAT development. Brown adipose tissues were collected from Prdm16 knockout and wiletype mice with 4 biological replicates per condition. Experiment was done in two separate batch for 6-week-old and 11-month-old. Extracted RNA was hybridized to Agilent two-color arrays.

2014-04-09 | E-GEOD-55080 | biostudies-arrayexpress

Tlx (nr2e1)-dependent gene expression in adult neural stem cells

Project description:Tlx (nr2e1) is an orphan nuclear receptor that is highly expressed in proliferating neural stem cells (NSCs) in the adult mouse forebrain. The goal was to identify Tlx-regulated genes in this specific cell population. Two populations of Tlx-positive neural stem cells were isolated from 2-month-old male mice based on a LacZ marker that was knocked into the Tlx locus. The first population, Tlx(f/Z;CreER), contains a floxed allele of Tlx (f), the LacZ marker (Z), and a CreER fusion transgene. Addition of tamoxifen (4OH-tamoxifen) into this NSC population leads to Cre-mediated deletion of the floxed allele of Tlx. The second NSC population, Tlx(f/Z), does not contain a CreER transgene; thus it does not respond to tamoxifen treatment and was used as a control. Keywords: Nuclear receptor-dependent gene expression

2008-12-01 | GSE9981 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data