Genomics

Dataset Information

0

The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress [ChIP-seq]


ABSTRACT: Organisms respond to mitochondrial stress by activating multiple defense pathways including the mitochondrial unfolded protein response (UPRmt). However, how different layers of UPRmt regulators are orchestrated to transcriptionally activate the stress responses remains largely unknown. Here we identified CBP-1, the worm ortholog of the mammalian acetyltransferases CBP/p300, as an essential regulator for UPRmt activation, as well as for mitochondrial stress-induced immune response, amyloid-β aggregation reduction and lifespan extension in Caenorhabditis elegans. Mechanistically, CBP-1 acts downstream of histone demethylases, JMJD-1.2/JMJD-3.1, and upstream of UPRmt transcription factors including ATFS-1, to systematically induce a broad spectrum of UPRmt genes and execute multiple beneficial functions. In mouse and human populations, transcript levels of CBP/p300 positively correlate with UPRmt transcripts and longevity. Furthermore, CBP/p300 inhibition disrupts, while forced expression of p300 is sufficient to activate, the UPRmt in mammalian cells. These results highlight an evolutionarily conserved mechanism that determines mitochondrial stress response, and promotes health and longevity through CBP/p300.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE148328 | GEO | 2020/12/07

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-12-07 | GSE156830 | GEO
2020-12-07 | GSE131613 | GEO
2020-12-07 | GSE131611 | GEO
2016-05-03 | GSE78990 | GEO
2022-09-23 | GSE179517 | GEO
2021-09-01 | GSE158628 | GEO
2016-06-28 | E-GEOD-75247 | biostudies-arrayexpress
2016-06-28 | E-GEOD-75410 | biostudies-arrayexpress
2024-03-13 | GSE261565 | GEO
2020-07-31 | GSE143904 | GEO