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Gene expression profiling of erlotinib-resistant PC9 cells.

ABSTRACT: The non-small cell lung carcinoma (NSCLC) PC9 cell line is an established preclinical model for tyrosine kinase inhibitors. To better understand gene expression changes in cells that survived the inhibitor treatment, we treated the EGFR-mutant PC9 cells with erlotinib, isolated RNA, and performed RNA-seq analysis. We were able to identify genes that are differentially expressed in erlotinib-treated cells compared to untreated. The results of this study will be integrated with single cell RNA-seq to address the utility of bulk RNA versus single cell RNA strategies in identifying biomarkers of drug resistance.

ORGANISM(S): Homo sapiens

PROVIDER: GSE148465 | GEO | 2020/12/19

REPOSITORIES: GEO

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