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Genome wide status of endometrial stromal cells stimulated by cAMP, and cAMP under C/EBPb-knockdown

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE148622 | GEO | 2021/02/17

REPOSITORIES: GEO

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Genome wide H3K27ac status of endometrial stromal cells stimulated by cAMP, and cAMP under C/EBPb-knockdown

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Genome wide status of endometrial stromal cells stimulated by cAMP, and cAMP under C/EBPb-knockdown

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Genome wide RNA expression profile of endometrial stromal cells stimulated by cAMP, and cAMP under PGC-1a-knockdown

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Genome wide RNA expression profile of endometrial stromal cells stimulated by cAMP, and cAMP under C/EBPb-knockdown

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Genome wide RNA expression profile of endometrial stromal cells stimulated by cAMP, and cAMP under PGC-1a-knockdown

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Genome wide RNA expression profiles of endometrial stromal cells stimulated by cAMP, cAMP+MPA, MPA and E2+MPA.

Project description:To know the differences of decidualization induced by different stimuli, we compared the mRNA expression profiles of decidualized ESCs stimulated by cAMP or cAMP+MPA for 4 days, or by MPA or E2+MPA for 14 days.

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Genome-wide DNA methylation analysis revealed stable DNA methylation status during decidualization in human endometrial stromal cells.

Project description:BackgroundDuring decidualization in endometrial stromal cells (ESCs), expressions of a number of genes and epigenetic modifications of histones are altered. However, there is little information about whether DNA methylation, which is another epigenetic mechanism, also changes during decidualization. Here, we examined the genome-wide DNA methylation profiles in ESCs during decidualization and their associations with the changes of gene expressions and histone modifications.ResultsESCs were incubated with estradiol and medroxyprogesterone acetate for 14 days to induce decidualization. The genome-wide DNA methylation profiles were compared between the non-decidualized ESCs and the decidualized ESCs. Of 482,005 CpGs, only 23 CpGs (0.0048%) showed different DNA methylation statuses. The DNA methylation statuses of the differentially expressed genes and the regions with different histone modifications (H3K4 tri-methylation and H3K27 acetylation) were also compared between the ESCs. In the upregulated and downregulated genes in decidualized ESCs, DNA methylation statuses around the promoter region of the genes did not significantly differ between the ESCs. In the regions with different histone modification, DNA methylation statuses did not differ between the ESCs. The differentially expressed genes and the differential histone modification regions were hypomethylated.ConclusionsCulturing ESCs with estrogen/progesterone did not distort the physiological pattern of DNA methylation, although mRNA expression and histone modifications were dynamically altered. A genome-wide DNA methylation analysis revealed stable DNA methylation statuses during decidualization in human endometrial stromal cells. DNA hypomethylation is maintained for the variable changes of histone modifications and gene expression during decidualization.

| S-EPMC6489213 | biostudies-literature

Correction: Genome-wide DNA methylation analysis revealed stable DNA methylation status during decidualization in human endometrial stromal cells.

Project description: Not available

| S-EPMC10996215 | biostudies-literature