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Gene expression profiling of chondrodysplasia mutants and isogenic controls during hypertrophic induction from iPSCs

ABSTRACT: In order to better understand chondrodysplasia disease mechanisms, we induced hypertrophic chondrocytes from chondrodysplasia-specific iPSCs and analyzed their gene expression profile. This dataset includes the expression data obtained from iPSC-derived cartilage pellets on day 56 of hypertrophic induction. Three COL10A1 mutants and two MATN3 mutants were compared to their isogenic controls to determine the effects of each mutation on the unfolded protein response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE148728 | GEO | 2020/05/20

REPOSITORIES: GEO

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