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Differential gene expression in miR-146a-/- vs. WT hematopoietic stem and progenitor cells [miR146aKO_vs_WT_RNA-seq_bulk]

ABSTRACT: To identify pathways and processes driving the observed hematopoietic stem cell (HSC) aging-like phenotypes in miR-146a-/- vs. WT, we performed RNA-seq gene expression profiling of Lin- Sca-1+ c-Kit+ (LSK) cells isolated from miR-146a-/- or WT mouse bone marrow (BM). Differential expression analysis and EnrichmentMap network analysis identified cytokine signalling and immune pathways as potential drivers of aging-like alterations in miR-146a-/- HSC proliferation and differentiation.

ORGANISM(S): Mus musculus

PROVIDER: GSE148990 | GEO | 2020/05/14

REPOSITORIES: GEO

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