Transcriptomics

Dataset Information

0

Inactivation of RNase P in Escherichia coli significantly changes post-transcriptional RNA metabolism


ABSTRACT: Ribonuclease P (RNase P) is the only ribonuclease responsible for 5'-end maturation of tRNAs in all kingdoms of life. In Escherichia coli, it is also essential for separation of pre-tRNAs from multiple polycistronic transcripts. Using RNA sequencing (RNA-seq), we show here that RNase P affects the abundance of ~44% of the expressed mRNAs demonstrating a much more widespread role in mRNA decay than previously thought. Furthermore, our data also demonstrate for the first time that the polyadenylation of transcripts by PAP I modulates RNase P-mediated mRNA decay as well as tRNA processing.

ORGANISM(S): Escherichia coli

PROVIDER: GSE149024 | GEO | 2021/09/09

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2006-03-08 | GSE4383 | GEO
2006-03-07 | E-GEOD-4383 | biostudies-arrayexpress
2021-01-18 | GSE158044 | GEO
2017-12-31 | GSE94830 | GEO
2015-09-23 | GSE73334 | GEO
2014-09-11 | E-GEOD-42314 | biostudies-arrayexpress
2018-05-12 | GSE108295 | GEO
2023-09-04 | GSE223876 | GEO
2011-11-17 | E-GEOD-33756 | biostudies-arrayexpress
2024-05-29 | GSE250347 | GEO