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Role of the histone methylase G9a in pancreatic carcinogenesis

ABSTRACT: Accumulating evidences propose the importance of epigenetic regulation in pancreatic carcinogenesis, but the mechanistic insights of a variety of histone modification process still remains to be elucidated. G9a functions as a transcriptional repressor via the methylating activity specific for histone H3 lysine9. We identified G9a as a critical factor in the development of murine pancreatic oncogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE149093 | GEO | 2020/11/03

REPOSITORIES: GEO

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Role of the histone methylase G9a in pancreatic carcinogenesis

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Transcription profiling of mouse embryonic fibroblasts deleted for G9a reconstituted with empty vector (delta), wild type FLAG-G9a (WT), FLAG-G9a K165A (K165A) or FLAG-G9a H1093K catalytic mutant reveasl methylation of hMTase G9a on a histone-like site regulates protein complex assembly

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Combined double knockout of Ezh2 and G9a leads to expression change in murine retinal ganglion cells

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2017-08-30 | GSE93690 | GEO

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation

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Histone H3K9 Methyltransferase G9a Represses PPARγ Expression and Adipogenesis [Affymetrix expression data]

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