Transcriptomics

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Inhibition of BRD4 Rescues Cardiac phenotype in Myocyte-Specific Lamin A/C Null Mice


ABSTRACT: Deletion of Lmna, encoding nuclear membrane protein LMNA, specifically in mouse cardiac myocytes activates BRD4 and leads to heart failure, arrhythmias, myocardial fibrosis, apoptosis, and premature death, which were partially rescued upon inhibition of BRD4.

ORGANISM(S): Mus musculus

PROVIDER: GSE149095 | GEO | 2023/03/19

REPOSITORIES: GEO

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