Transcriptomics

Dataset Information

0

Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism


ABSTRACT: Hepatic metabolic derangements are key components in the development of fatty liver, insulin resistance, and atherosclerosis. SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient availability. Here we demonstrate that hepatic SIRT1 regulates fatty acid metabolism by positively regulating PPAR-alpha. Hepatocyte-specific deletion of SIRT1 impairs PPAR-alpha signaling and decreased fatty acid beta-oxidation in the liver. When challenged with a high-fat diet, liver-specific SIRT1 knockout mice develop hepatic steatosis, hepatic inflammation, and endoplasmic reticulum stress. Taken together, our data indicate that SIRT1 plays a vital role in the regulation of hepatic lipid homeostasis.

ORGANISM(S): Mus musculus

PROVIDER: GSE14921 | GEO | 2009/04/07

SECONDARY ACCESSION(S): PRJNA111907

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-03-28 | E-GEOD-56321 | biostudies-arrayexpress
2014-03-28 | GSE56321 | GEO
2022-06-08 | GSE202302 | GEO
2012-03-29 | E-GEOD-35075 | biostudies-arrayexpress
2017-02-22 | GSE94904 | GEO
2012-03-30 | GSE35075 | GEO
2020-10-09 | GSE134625 | GEO
2008-10-07 | GSE13044 | GEO
2021-10-08 | GSE151281 | GEO
2013-08-21 | E-GEOD-50028 | biostudies-arrayexpress