A ribosomal assembly stress response governed by the methionine cycle extends lifespan in C. elegans mutant with defective de novo proline biogenesis
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ABSTRACT: We compared the ratio of polysome-associated mRNAs (>3 ribosomes/mRNA) normalized to total mRNA levels between WT and pycr-1(wrm22) mutants. While mRNA translation as measured by polysome profiling was not affected in pycr-1 mutants, we detected significant changes in the translation of mRNAs involved in ribogenesis. Ribosomal stress can activate HSF-1 and indeed a transcriptome analysis of pycr-1 mutants revealed a significant change in HSF-1 target gene expression.
ORGANISM(S): Caenorhabditis elegans
PROVIDER: GSE149325 | GEO | 2023/04/23
REPOSITORIES: GEO
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