Transcriptomics

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Recombinant RANKL causes modulation of inflammatory signaling pathways in C2C12 myotubes


ABSTRACT: Previous reports indicate that RANKL-RANK signaling participates in regulating muscle mass and strength in denervated animals, while RANKL inhibition by OPG-Fc peptide improves the muscle phenotype in dystrophic mdx mice. RANKL has also been shown to activate STAT3 to regulate osteoclastogenesis, although it is not known whether such interaction also plays a role in skeletal muscle. The objective of this aim is to clarify whether RANKL directly affects skeletal muscle.

ORGANISM(S): Mus musculus

PROVIDER: GSE149606 | GEO | 2022/03/30

REPOSITORIES: GEO

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