Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genomic comparisons of Salmonella enterica serovar Paratyphi A isolates

ABSTRACT: Comparative genomic analysis of a temporally and locally diverse set of S. enterica ssp I sv Paratyphi A isolates Keywords: ordered

ORGANISM(S): Salmonella enterica Salmonella enterica subsp. enterica serovar Paratyphi A

PROVIDER: GSE1500 | GEO | 2004/07/21

SECONDARY ACCESSION(S): PRJNA90825

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genomic comparisons of Salmonella enterica serovar Paratyphi A isolates

Project description:Comparative genomic analysis of a temporally and locally diverse set of S. enterica ssp I sv Paratyphi A isolates Keywords: ordered

2004-07-21 | E-GEOD-1500 | biostudies-arrayexpress

Genomic comparisons of Salmonella enterica serovar Enteritidis isolates

Project description:Comparative genomic hybridization of a temporally and locally diverse set of S. enterica ssp I serovar Enteritidis isolates, and some closely related serovar Dublin and Gallinarum strains, to the sequenced Enteritidis PT4 Keywords: other

2005-08-06 | GSE2242 | GEO

Genomic comparisons of Salmonella enterica serovar Enteritidis isolates

2005-08-06 | E-GEOD-2242 | biostudies-arrayexpress

High-throughput gene expression profiling of Salmonella enterica serovar Paratyphi A in the blood of bacteremic patients in Bangladesh

Project description:In this work, we applied an RNA analysis method, Selective Capture of Transcribed Sequences (SCOTS), and cDNA hybridization-microarray technology to identify S. Paratyphi A transcripts expressed by bacteria in the blood of three patients in Bangladesh. In total, we detected 1798 S. Paratyphi A mRNAs expressed in the blood of infected humans (43.9% of the ORFeome). Of these, we identified 868 in at least two patients, and 315 in all three patients. S. Paratyphi A transcripts identified in at least two patients encode proteins involved in energy metabolism, nutrient and iron acquisition, vitamin biosynthesis, stress responses, oxidative stress resistance, and pathogenesis. A number of detected transcripts are expressed from PhoP and SlyA-regulated genes associated with intra-macrophage survival, genes contained within Salmonella Pathogenicity Islands (SPIs) 1-4, 6, 10, 13, and 16, as well as RpoS-regulated genes. The largest category of identified transcripts are those encoding proteins with unknown function. When comparing level of bacterial mRNA detection using in vivo samples collected from infected patients to samples from in vitro grown organisms, we found significant differences for 347, 391, and 456 S. Paratyphi A transcripts in each of three individual patients (approximately 9.7% of the ORFeome). Of these, expression of 194 transcripts (4.7% of ORFs) was concordant in two or more patients, and 41 in all patients. Genes encoding these transcripts are contained within SPI-1, 3, 6 and 10, are PhoP-regulated genes, are involved in energy metabolism, nutrient acquisition, drug resistance, or are uncharacterized genes. Using quantitative RT-PCR, we confirmed increased gene expression in vivo for a subset of genes identified in our analyses. We compared transcriptional profiles of S. Paratyphi A from the blood of infected humans to S. Paratyphi A grown in vitro. Replicates and dye-swaps were performed.

2010-09-06 | E-GEOD-22958 | biostudies-arrayexpress

SARB48_hydrogen_peroxide_2mM_DNA

Project description:Gene content of Salmonella enterica sv Paratyphi C SARB48 5h after treatment with 2mM hydrogen peroxide Keywords: parallel sample

2004-05-10 | GSE825 | GEO

Salmonella enterica subsp. enterica serovar Paratyphi A

Project description:Salmonella enterica subsp. enterica serovar Paratyphi A Genome sequencing

| PRJNA1106742 | ENA

High-throughput gene expression profiling of Salmonella enterica serovar Paratyphi A in the blood of bacteremic patients in Bangladesh

2010-09-06 | GSE22958 | GEO

SARB48_hydrogen_peroxide_2mM_DNA

Project description:Gene content of Salmonella enterica sv Paratyphi C SARB48 5h after treatment with 2mM hydrogen peroxide

2010-06-09 | E-GEOD-825 | biostudies-arrayexpress

Salmonella enterica subsp. enterica serovar Paratyphi A

Project description:Salmonella enterica subsp. enterica serovar Paratyphi A Raw sequence reads

| PRJNA775815 | ENA