Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Global circadian transcript profile of mouse heart entrained by inverted feeding

ABSTRACT: Circadian clocks in peripheral organs are entrained by feeding. Eating in the right time is crucial to maintain metabolic health, whereas eating in the wrong time increases the susceptibility to metabolic diseases. It is unknown how change of mealtime impacts circadian transcriptomes in peripheral organs and brain, such as liver, heart, kidney and visceral adipose tissue. Here, we presented global circadian transcript profile of mouse heart entrained by inverted feeding to compile an atlas for mechanistic insights into how feed-fast cycle regulates circadian biology.

ORGANISM(S): Mus musculus

PROVIDER: GSE150381 | GEO | 2021/03/11

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Global circadian transcript profile of mouse kidney entrained by inverted feeding

Project description:Circadian clocks in peripheral organs are entrained by feeding. Eating in the right time is crucial to maintain metabolic health, whereas eating in the wrong time increases the susceptibility to metabolic diseases. It is unknown how change of mealtime impacts circadian transcriptomes in peripheral organs and brain, such as liver, heart, kidney and visceral adipose tissue. Here, we presented global circadian transcript profile of mouse kidney entrained by inverted feeding to compile an atlas for mechanistic insights into how feed-fast cycle regulates circadian biology.

2021-03-11 | GSE151221 | GEO

Global circadian transcript profile of mouse liver entrained by inverted feeding

Project description:Circadian clocks in peripheral organs are entrained by feeding. Eating in the right time is crucial to maintain metabolic health, whereas eating in the wrong time increases the susceptibility to metabolic diseases. It is unknown how change of mealtime impacts circadian transcriptomes in peripheral organs and brain, such as liver, heart, kidney and visceral adipose tissue. Here, we presented global circadian transcript profile of mouse liver entrained by inverted feeding to compile an atlas for mechanistic insights into how feed-fast cycle regulates circadian biology.

2021-03-11 | GSE150380 | GEO

Global circadian transcript profile of mouse viceral adipose entrained by inverted feeding

Project description:Circadian clocks in peripheral organs are entrained by feeding. Eating in the right time is crucial to maintain metabolic health, whereas eating in the wrong time increases the susceptibility to metabolic diseases. It is unknown how change of mealtime impacts circadian transcriptomes in peripheral organs and brain, such as liver, heart, kidney and visceral adipose tissue. Here, we presented global circadian transcript profile of mouse visceral adipose tissue entrained by inverted feeding to compile an atlas for mechanistic insights into how feed-fast cycle regulates circadian biology.

2021-03-11 | GSE151228 | GEO

Global circadian transcript profile of mouse anterior hypothalamus entrained by inverted feeding

Project description:Circadian clocks in peripheral organs are entrained by feeding. Eating in the right time is crucial to maintain metabolic health, whereas eating in the wrong time increases the susceptibility to metabolic diseases. It is unknown how change of mealtime impacts circadian transcriptomes in peripheral organs and brain, such as liver, heart, kidney and visceral adipose tissue. Here, we presented global circadian transcript profile of mouse tissues (i.e. kidney, anterior hypothalamus) entrained by inverted feeding to compile an atlas for mechanistic insights into how feed-fast cycle regulates circadian biology.

2021-03-11 | GSE150958 | GEO

Global circadian transcript profile of mouse gastrocnemius muscle entrained by inverted feeding

Project description:Circadian clocks in peripheral organs are entrained by feeding. Eating in the right time is crucial to maintain metabolic health, whereas eating in the wrong time increases the susceptibility to metabolic diseases. It is unknown how change of mealtime impacts circadian transcriptomes in peripheral organs and brain. Here, we presented global circadian transcript profile of mouse tissues (i.e. skeletal muscle) entrained by inverted feeding to compile an atlas for mechanistic insights into how feed-fast cycle regulates circadian biology.

2023-04-23 | GSE194106 | GEO

Global circadian transcript profile of mouse peripheral tissues and brain entrained by inverted feeding

Project description:Global circadian transcript profile of mouse peripheral tissues and brain entrained by inverted feeding

| PRJNA631956 | ENA

Mouse cerebellum LC-MSMS: effect of calorie restriction

Project description:The cerebellum harbors a circadian clock that can be shifted by scheduled mealtime and participates in behavioral anticipation of food access. To determine which cerebellar proteins are modified by time-of-day and/or feeding time, we determined day-night variations of proteome in the cerebellum of mice fed either ad libitum or only during daytime (from noon to lights off). Two-dimensional differences in gel electrophoresis (2D-DIGE) combined with two-way analyses of variance reveals that a majority of cerebellar proteins are significantly regulated by feeding conditions (food availability). Levels of few other cerebellar proteins were modulated exclusively by daily (or circadian) cues, independent of meal time, and others due to combined influence of meal time and time-of-day. Changes reflect behavioral anticipation of mealtime and/or feeding-induced shift in the circadian clock of the cerebellum.

2021-04-06 | PXD021056 | Pride

Misaligned feeding uncouples daily rhythms within brown adipose tissue and between peripheral clocks

Project description:Extended consumption of food into the rest period perturbs the phase relationship between circadian clocks in the periphery and the brain and has deleterious effects on health through mechanisms that remain incompletely understood. Beyond the liver, how other metabolic organs respond to hypocaloric diet (amount and timing) is largely unexplored. We investigated how feeding time impacts circadian gene expression in white (eWAT) and brown (BAT) adipose tissues in comparison to liver and hypothalamus. With automated feeders, we restricted food to either daytime or nighttime in C57BL/6J male mice, with or without caloric restriction. We found tissue-specific changes in the phase and amplitude of genome-wide mRNA expression patterns induced by daytime feeding in liver and eWAT, whereas BAT exhibited resilience and remained predominately entrained to the light-dark cycle, similar to hypothalamus. We uncovered an internal split within the BAT in response to conflicting environmental cues, displaying inverted oscillations on a subset of metabolic genes without modifying its local core circadian machinery. Integrating intra- and inter-tissue disruptions in circadian clock-controlled transcriptional networks with metabolic outcomes may help elucidate the mechanism underlying the health burden of eating at the wrong time of the day.

2024-07-25 | GSE266543 | GEO

Light-entrained and brain-tuned circadian circuits regulate ILC3 and gut homeostasis

Project description:Group 3 innate lymphoid cells (ILC3) are major regulators of inflammation, infection, microbiota composition and metabolism. ILC3 and neuronal cells were shown to interact at discrete mucosal locations to steer mucosal defence. Nevertheless, whether neuroimmune circuits operate at an organismal level, integrating extrinsic environmental signals to orchestrate ILC3 responses remains elusive. Here we show that light-entrained and brain-tuned circadian circuits regulate enteric ILC3, intestinal homeostasis and the host lipid metabolism. We found that enteric ILC3 display circadian expression of clock genes and ILC3-related transcription factors. ILC3-autonomous ablation of the circadian regulator Arntl led to disrupted gut ILC3 homeostasis, impaired epithelial reactivity, deregulated microbiome, increased susceptibility to bowel infection and disrupted lipid metabolism. Loss of ILC3-intrinsic Arntl shaped the gut postcode receptors of ILC3. Strikingly, light-dark cycles, feeding rhythms and microbial cues differentially regulated ILC3 clocks, with light signals as major entraining cues of ILC3. Accordingly, surgical- and genetically-induced deregulation of brain rhythmicity led to disrupted circadian ILC3 oscillations, deregulated microbiome and altered lipid metabolism. Our work reveals a circadian circuitry that translates environmental light cues into enteric ILC3, shaping intestinal health and organismal homeostasis.

2019-08-02 | GSE135235 | GEO

Project description:Global circadian transcript profile of mouse heart entrained by inverted feeding

| PRJNA631106 | ENA