Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Generation of blastocyst-like structures from human embryonic stem cells I [scRNA-seq]

ABSTRACT: We established a method that enables the generation of blastocyst-like structures from human pluripotent stem cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE150570 | GEO | 2021/01/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Generation of blastocyst-like structures from human embryonic stem cells III [scRNA-seq]

Project description:We established a method that enables the generation of blastocyst-like structures from human pluripotent stem cells.

2021-01-24 | GSE163445 | GEO

Generation of blastocyst-like structures from human embryonic stem cells II [scRNA-seq]

Project description:We established a method that enables the generation of blastocyst-like structures from human pluripotent stem cells.

2021-01-24 | GSE163423 | GEO

Pig Synthetic Blastocyst-like Structures from Embryonic Stem Cells

Project description:We developed an efficient method to generate porcine blastocyst-like structures (termed blastoids) from ESCs.

2024-06-30 | GSE242553 | GEO

Generation of human blastocyst-like structures from pluripotent stem cells

Project description:Generation of human blastocyst-like structures from pluripotent stem cells

| PRJNA667174 | ENA

Generation of human blastocyst-like structures from pluripotent stem cells

Project description:Generation of human blastocyst-like structures from pluripotent stem cells

| PRJNA727994 | ENA

Generation of Blastocyst-like Structures from Extended Pluripotent Stem Cells

Project description:Generation of Blastocyst-like Structures from Extended Pluripotent Stem Cells

| PRJNA558254 | ENA

Generation of human blastocyst-like structures from pluripotent stem cells

Project description:Generation of human blastocyst-like structures from pluripotent stem cells

| PRJEB44768 | ENA

Generation of blastocyst-like structures from human embryonic stem cells

Project description:Generation of blastocyst-like structures from human embryonic stem cells

| PRJNA632839 | ENA

Generation of Blastocyst-like Structures from Extended Pluripotent Stem Cells

Project description:A single mouse blastomere from until 8-cell embryo can generate an entire blastocyst. Whether blastomere-like extended pluripotent stem cells (EPS cells) retain a similar generative capacity remains unknown. Here, we established a 3D differentiation system that enabled the generation of blastocyst-like structures from EPS cells (EPS-blastoids) through lineage segregation and self-organization. EPS-blastoids resembled blastocysts in morphology and cell lineage allocation. EPS-blastoids formation recapitulated key morphogenetic events during preimplantation and early postimplantation development in vitro. Upon transfer, some EPS-blastoids underwent implantation, induced decidualization, and generated live, albeit disorganized, tissues in utero. Single cell and bulk RNA-sequencing analysis revealed that EPS-blastoids contained all three blastocyst cell lineages and shared transcriptional similarity with natural blastocysts. We also provide proof-of-concept that EPS-blastoids can be generated from somatic cells via cellular reprograming. EPS-blastoids provide a unique platform for studying early embryogenesis, and pave the way to generate viable synthetic embryos using cultured cells.

2019-08-03 | GSE135289 | GEO

Generation of blastocyst-like structures from human embryonic stem cells III [scRNA-seq]

Project description:Generation of blastocyst-like structures from human embryonic stem cells III [scRNA-seq]

| PRJNA686112 | ENA